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Drug

Tryptophan

In clinical development
Actively researchedLate-stage developmentSteady momentum
Also known as (2S)-2-amino-3-(1H-indol-3-yl)propanoic acid, (S)-Tryptophan, (S)-alpha-Amino-beta-(3-indolyl)-propionic acid, Aminosyn 10%, Sulfite-Free+45 more

(2S)-2-amino-3-(1H-indol-3-yl)propanoic acid, (S)-Tryptophan, (S)-alpha-Amino-beta-(3-indolyl)-propionic acid, Aminosyn 10%, Sulfite-Free, Aminosyn 3.5 % M, Sulfite Free, Aminosyn 8.5 % with Electrolytes, Sulfite-Free, Aminosyn 8.5%, Sulfite-Free, Aminosyn II 10 %, Aminosyn II 15%, Aminosyn II 8.5 % with Electrolytes, Sulfite-Free, Aminosyn II 8.5 %, Sulfite-Free, Aminosyn-HBC 7 %, Sulfite-Free, Aminosyn-PF 10 %, Sulfite-Free, Aminosyn-PF 7%, Clinisol 15, Freamine III 10, Hepatamine 8, Hepatasol, L-(-)-Tryptophan, L-TRYPTOPHAN, Nephramine, Plenamine, PremaSol, ProSol, ProcalAmine 3, Restone, Somnicin, Travasol 10, Travasol 10%, Triptofano, Trophamine, Trophamine 10 %, Trophamine 6 %, Trp, W, Tryptophane, Clinimix 4.25/10, Clinimix 4.25/25, Clinimix 4.25/5, Clinimix 5/15, Clinimix 5/20, Clinimix 5/25, Clinimix E 2.75/5, Clinimix E 4.25/10, Clinimix E 4.25/5, Clinimix E 5/15, Clinimix E 5/20, Clinimix E 5/25, Tryptophanum.

30
Research papers
1
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

The Effects of Kynurenine Aminotransferase Inhibition in People With Schizophrenia

Clinical trial2026-02-11Results posted · ClinicalTrials.gov

Neuroimaging of Tryptophan Challenge in People With Schizophrenia and Healthy Controls

Clinical trial2024-07-30Results posted · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Tryptophan
Aliases & brands
(2S)-2-amino-3-(1H-indol-3-yl)propanoic acid(S)-Tryptophan(S)-alpha-Amino-beta-(3-indolyl)-propionic acidAminosyn 10%, Sulfite-FreeAminosyn 3.5 % M, Sulfite FreeAminosyn 8.5 % with Electrolytes, Sulfite-FreeAminosyn 8.5%, Sulfite-FreeAminosyn II 10 %Aminosyn II 15%Aminosyn II 8.5 % with Electrolytes, Sulfite-FreeAminosyn II 8.5 %, Sulfite-FreeAminosyn-HBC 7 %, Sulfite-FreeAminosyn-PF 10 %, Sulfite-FreeAminosyn-PF 7%Clinisol 15Freamine III 10Hepatamine 8HepatasolL-(-)-TryptophanL-TRYPTOPHANNephraminePlenaminePremaSolProSolProcalAmine 3RestoneSomnicinTravasol 10Travasol 10%TriptofanoTrophamineTrophamine 10 %Trophamine 6 %TrpWTryptophaneClinimix 4.25/10Clinimix 4.25/25Clinimix 4.25/5Clinimix 5/15Clinimix 5/20Clinimix 5/25Clinimix E 2.75/5Clinimix E 4.25/10Clinimix E 4.25/5Clinimix E 5/15Clinimix E 5/20Clinimix E 5/25Tryptophanum
RxNorm CUI
10898
ChEMBL ID
CHEMBL54976
ATC codes
N06AX02
UNII
8DUH1N11BX

Clinical trials

6 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
6
registered trials across all phases
LATEST COMPLETION 2024
1
Active studies
1
Recruiting
4
Late-stage (III+)
4
Completed
1
Discontinued
PHASE DISTRIBUTIONn = 6
Phase 1 / 21Phase 21Phase 2 / 31Phase 41Phase N / A2

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Recent completions

Trials that read out recently, adding to the completed evidence base.

The Effects of Kynurenine Aminotransferase Inhibition in People With Schizophrenia

CompletedPH I/IIUniversity of Maryland, Baltimoren=882024

Neuroimaging of Tryptophan Challenge in People With Schizophrenia and Healthy Controls

CompletedPH II/IIIUniversity of Maryland, Baltimoren=932019

Tryptophan and Behavior Therapy for Cocaine Abuse

CompletedPH IINational Institute on Drug Abuse (NIDA)n=2002001

Research activity

30 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20062025
Most influential
Recent papers
Major research themes8
Gastrointestinal Microbiome11Tryptophan6Kynurenine3Microbiota3Serotonin3Indoles2Mental Disorders2Adenocarcinoma of Lung1
Journals, researchers & institutions
Top journals
  • International journal of molecular sciences5
  • Frontiers in immunology4
  • Cells2
  • Microbiome2
  • British journal of cancer1
  • Cell communication and signaling : CCS1
Leading researchers
  • Fan Y2
  • Ge Y2
  • Licht TR2
  • Roager HM2
  • Tanaka M2
  • Vécsei L2
  • Wang Y2
  • Agus A1
Leading institutions
free-text, unnormalised
  • Interdisciplinary Excellence Centre2
  • National Food Institute2
  • Stanford University2
  • Stanford University School of Medicine2
  • University of Copenhagen2
  • Advanced Center for Chronic Diseases (ACCDiS)1

Related diseases

9 conditions

Regulator-approved indications and conditions co-mentioned with this drug across the research literature. Number shows shared papers.

Related drugs

8 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Studied across 11 of the same disease areas as Tryptophan in the shared literature.

11 shared diseases1 shared paper

Studied across 8 of the same disease areas as Tryptophan in the shared literature.

8 shared diseases1 shared paper

Studied across 6 of the same disease areas as Tryptophan in the shared literature.

6 shared diseases1 shared paper

Studied across 5 of the same disease areas as Tryptophan in the shared literature.

5 shared diseases1 shared paper

Studied across 3 of the same disease areas as Tryptophan in the shared literature.

3 shared diseases2 shared papers

Studied across 3 of the same disease areas as Tryptophan in the shared literature.

3 shared diseases1 shared paper

Studied across 2 of the same disease areas as Tryptophan in the shared literature.

2 shared diseases1 shared paper

Studied across the same disease area as Tryptophan in the shared literature.

1 shared disease1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials