NOD2

Gene

nucleotide binding oligomerization domain containing 2

HGNCHGNC:5331 EnsemblENSG00000167207 NCBI Gene64127

Locus: gene with protein productLocation: 16q12.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Nucleotide-binding oligomerization domain-containing protein 2Q9HC29

Protein · therapeutic target

Clinically validated target · 1 approved medicine against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asIBD1 · CARD15 · BLAU · CD · PSORAS1 · CLR16.3 · NLRC2

View full nomenclature history (11)

Previous symbolsIBD1, CARD15

Alias symbolsBLAU, CD, PSORAS1, CLR16.3, NLRC2

Previous namescaspase recruitment domain family, member 15

Alias namesNOD-like receptor C2, NLR family, CARD domain containing 2, nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Crohn's Disease

Inflammatory Bowel Diseases

Behcet's Syndrome

Enteritis

Asthma

Childhood onset asthma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

NLR familyCaspase recruitment domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.