ULK1

Gene

unc-51 like autophagy activating kinase 1

HGNCHGNC:12558 EnsemblENSG00000177169 NCBI Gene8408

Locus: gene with protein productLocation: 12q24.33

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Serine/threonine-protein kinase ULK1O75385

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asATG1 · ATG1A

View full nomenclature history (5)

Alias symbolsATG1, ATG1A

Previous namesunc-51 (C. elegans)-like kinase 1, unc-51-like kinase 1 (C. elegans)

Alias namesATG1 autophagy related 1 homolog (S. cerevisiae)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases

Lysosomal Storage Diseases

Carcinoma, Hepatocellular

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Autophagy relatedUnc-51 like kinase family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2026-04-02.

Open TargetsGene–disease associations from the Open Targets Platform.