Drug

Adenosine Triphosphate

In clinical development

Emerging researchLate-stage developmentCooling momentum

Also known as ATP, ADT - Adenosine triphosphate, ATP - Adenosine triphosphate, Adenosine 5'-triphosphate+1 more

ATP, ADT - Adenosine triphosphate, ATP - Adenosine triphosphate, Adenosine 5'-triphosphate, Adenosine-5'-triphosphate.

RxNorm318 ChEMBLCHEMBL14249UNII8L70Q75FXE

Research papers

Active clinical trials

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

The Safety, Feasibility, and Repeatability of Inhaled ATP Cough Challenges

Clinical trial2026-08-01Primary completion · ClinicalTrials.gov

Randomized, Double-Blind Active-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of an ATP-Containing Parenteral Vitamin B Complex in Patients With Symptomatic Diabetic Polyneuropathy

Clinical trial2025-12-22Results expected Q1 2028 · ClinicalTrials.gov

MCU expression in hippocampal CA2 neurons modulates dendritic mitochondrial morphology and synaptic plasticity.

Research2025-02-06Scientific reports

Advances in myocardial energy metabolism: metabolic remodelling in heart failure and beyond.

Research2024-12-01Cardiovascular research

Mitochondrial pyruvate transport regulates presynaptic metabolism and neurotransmission.

Research2024-11-15Science advances

A Functional Magnetic Resonance Imaging Study to Investigate ATP-sensitive Cough Neural Pathways in Patients With Chronic Cough Hypersensitivity

Clinical trial2024-08-22Results posted · ClinicalTrials.gov

Electro-Metabolic Coupling of Cumulus-Oocyte Complex.

Research2024-05-14International journal of molecular sciences

A Double-blind Randomized Controlled Trial of Adenosine Disodium Triphosphate in Improving Moderate to Severe Depressions

Clinical trial2024-03-19Results expected Q4 2026 · ClinicalTrials.gov

Extracellular ATP inhibits excitatory synaptic input on parvalbumin positive interneurons and attenuates gamma oscillations via P2X4 receptors.

Research2024-01-31British journal of pharmacology

PFOS-elicited metabolic perturbation in liver and fatty acid metabolites in testis of adult mice.

Research2023-11-22Frontiers in endocrinology

The Immune Regulatory Role of Adenosine in the Tumor Microenvironment.

Research2023-10-05International journal of molecular sciences

Creatine supplementation enhances anti-tumor immunity by promoting adenosine triphosphate production in macrophages.

Research2023-08-18Frontiers in immunology

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Adenosine Triphosphate

Aliases & brands

ATPADT - Adenosine triphosphateATP - Adenosine triphosphateAdenosine 5'-triphosphateAdenosine-5'-triphosphate

RxNorm CUI

318

ChEMBL ID

CHEMBL14249

UNII

8L70Q75FXE

Clinical trials

11 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme

CLINICALTRIALS.GOV · LIVE REGISTRY

registered trials across all phases

LATEST COMPLETION 2022

Active studies

Recruiting

Late-stage (III+)

Completed

Discontinued

PHASE DISTRIBUTIONn = 11

Early Phase 12Phase 12Phase 22Phase 31Phase 41Phase N / A3

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Not yet recruitingPH IVEgyptian International Pharmaceutical Industries Con=2002029

Application of Adenosine 5'-Triphosphate (ATP) Infusions in Palliative Home Care

CompletedPH IIIMaastricht University Medical Centern=1002006

Recent completions

Trials that read out recently, adding to the completed evidence base.

A Functional Magnetic Resonance Imaging Study to Investigate ATP-sensitive Cough Neural Pathways in Patients With Chronic Cough Hypersensitivity

CompletedN/AStuart Mazzonen=582022

Pyridoxine, P2 Receptor Antagonism, and ATP-mediated Vasodilation in Young Adults

CompletedPH IColorado State Universityn=92021

A Time-to-effect Based Dosing Strategy in Cryoballoon Ablation of Patients With Paroxysmal Atrial Fibrillation. Results of the the plusONE Randomized Multicenter Trial

CompletedN/AFundación para la Investigación del Hospital Clínico de Valencian=1402016

Evaluating the Effectiveness of the Use of Intravenous Infusions of Adenosine Triphosphate (ATP) in Patients With Moderate Alzheimer's Disease and Severe: Double-blind Dose Finding Clinical Trial.

CompletedPH IISara Varean=202016

Application of Adenosine 5'-Triphosphate (ATP) Infusions in Palliative Home Care

CompletedPH IIIMaastricht University Medical Centern=1002006

A Phase I Study And Pharmacokinetics Of Adenosine 5'- Triphosphate (ATP) When Administered By Intravenous Infusion On A Multiple Weekly Dose Schedule To Patients With Advanced Malignancies (Solid Tumors)

CompletedPH IDartmouth-Hitchcock Medical Center2002

Research activity

21 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time

20102025

Most influential

Tumor glycolysis as a target for cancer therapy: progress and prospects.

Molecular cancer · 2013 · 1,009 cites

Myelination of the nervous system: mechanisms and functions.

Annual review of cell and developmental biology · 2014 · 731 cites

Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis.

Molecular psychiatry · 2012 · 625 cites

DAMPs and NETs in Sepsis.

Frontiers in immunology · 2019 · 467 cites

TNF-alpha and neuropathic pain--a review.

Journal of neuroinflammation · 2010 · 451 cites

Effects of Ketone Bodies on Brain Metabolism and Function in Neurodegenerative Diseases.

International journal of molecular sciences · 2020 · 276 cites

Related diseases

4 conditions

Regulator-approved indications and conditions co-mentioned with this drug across the research literature. Number shows shared papers.

Active research areas

Diabetes Mellitus, Type 22 Inflammation2 Metabolic Syndrome2 Neoplasms2

Related drugs

7 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Adenosine

Studied across 6 of the same disease areas as Adenosine Triphosphate in the shared literature.

6 shared diseases3 shared papers

Fluorouracil

Studied across 5 of the same disease areas as Adenosine Triphosphate in the shared literature.

5 shared diseases1 shared paper

Aspartic Acid

Studied across 4 of the same disease areas as Adenosine Triphosphate in the shared literature.

4 shared diseases1 shared paper

Camptothecin

Studied across 4 of the same disease areas as Adenosine Triphosphate in the shared literature.

4 shared diseases1 shared paper

Leucovorin

Studied across 4 of the same disease areas as Adenosine Triphosphate in the shared literature.

4 shared diseases1 shared paper

Testosterone

Studied across 3 of the same disease areas as Adenosine Triphosphate in the shared literature.

3 shared diseases1 shared paper

Creatine

Frequently co-studied with Adenosine Triphosphate in the research literature.

1 shared paper

References & data sources

RxNorm (U.S. National Library of Medicine) — drug identity
ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
Europe PMC — research literature
ClinicalTrials.gov — clinical trials