ARHGEF7

Gene

Rho guanine nucleotide exchange factor 7

HGNCHGNC:15607 EnsemblENSG00000102606 NCBI Gene8874

Locus: gene with protein productLocation: 13q34

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPIXB · DKFZp761K1021 · Nbla10314 · KIAA0142 · DKFZp686C12170 · BETA-PIX · COOL1 · P85SPR · P85 · P85COOL1 · P50BP · PAK3 · P50

View full nomenclature history (16)

Alias symbolsPIXB, DKFZp761K1021, Nbla10314, KIAA0142, DKFZp686C12170, BETA-PIX, COOL1, P85SPR, P85, P85COOL1, P50BP, PAK3, P50

Previous namesRho guanine nucleotide exchange factor (GEF) 7

Alias namesSH3 domain-containing proline-rich protein, PAK-interacting exchange factor beta

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Female reproductive system disorder

Placental abruption

Lupus Erythematosus, Systemic

Placental retention

Colorectal Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Pleckstrin homology domain containingDbl family Rho GEFs

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.