EFNB2

Gene

ephrin B2

HGNCHGNC:3227 EnsemblENSG00000125266 NCBI Gene1948

Locus: gene with protein productLocation: 13q33.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Ephrin-B2P52799

Protein · therapeutic target

Clinical-stage target · 1 candidate in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asEPLG5 · LERK5 · Htk-L · HTKL · MGC126226 · MGC126227 · MGC126228

View full nomenclature history (11)

Previous symbolsEPLG5

Alias symbolsLERK5, Htk-L, HTKL, MGC126226, MGC126227, MGC126228

Previous namesephrin-B2

Alias namesHTK ligand, ligand of eph-related kinase 5, eph-related receptor tyrosine kinase ligand 5

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Sleep Initiation and Maintenance Disorders

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Ephrins

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.