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WLS

Gene

Wnt ligand secretion mediator

HGNCHGNC:30238EnsemblENSG00000116729NCBI Gene79971
Locus: gene with protein productLocation: 1p31.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asC1orf139 · GPR177 · FLJ23091 · MRP · EVI · mig-14
View full nomenclature history (11)
Previous symbolsC1orf139, GPR177
Alias symbolsFLJ23091, MRP, EVI, mig-14
Previous nameschromosome 1 open reading frame 139, G protein-coupled receptor 177, wntless homolog (Drosophila), wntless Wnt ligand secretion mediator
Alias nameswntless homolog

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Osteoporosis
Bone Diseases
Glaucoma, Open-Angle
Osteoarthritis, Hip
Glaucoma
Alcohol drinking
Urolithiasis

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

MicroRNA protein coding host genes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.