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Drug

Glutamic Acid

In clinical development
Actively researchedLate-stage developmentRising momentum
Also known as (2S)-2-Aminopentanedioic acid, (S)-2-Aminopentanedioic acid, (S)-Glutamic acid, Glu+4 more

(2S)-2-Aminopentanedioic acid, (S)-2-Aminopentanedioic acid, (S)-Glutamic acid, Glu, L-Glutamic Acid, L-Glutaminic acid, ácido glutámico, Glutamic-L Acid.

53
Research papers
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Synapse-specific catecholaminergic modulation of neuronal glutamate release.

Research2024-12-30Proceedings of the National Academy of Sciences of the United States of America

Glutamic Acid to Decrease Vincristine Toxicity in Children With Cancer

Clinical trial2021-08-11Results posted · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Glutamic Acid
Aliases & brands
(2S)-2-Aminopentanedioic acid(S)-2-Aminopentanedioic acid(S)-Glutamic acidGluL-Glutamic AcidL-Glutaminic acidácido glutámicoGlutamic-L Acid
RxNorm CUI
25916
ChEMBL ID
CHEMBL575060
UNII
3KX376GY7L

Clinical trials

2 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
2
registered trials across all phases
LATEST COMPLETION 2012
2
Late-stage (III+)
2
Completed
PHASE DISTRIBUTIONn = 2
Phase 31Phase N / A1

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Glutamic Acid to Decrease Vincristine Toxicity in Children With Cancer

CompletedPH IIIUniversity of South Floridan=2502012

Recent completions

Trials that read out recently, adding to the completed evidence base.

Research activity

53 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
19902025
Most influential

Synaptic modifications in cultured hippocampal neurons: dependence on spike timing, synaptic strength, and postsynaptic cell type.

The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998 · 2,375 cites

Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior.

The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003 · 705 cites

Three-dimensional relationships between hippocampal synapses and astrocytes.

The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999 · 676 cites

Calcium influx via the NMDA receptor induces immediate early gene transcription by a MAP kinase/ERK-dependent mechanism.

The Journal of neuroscience : the official journal of the Society for Neuroscience · 1996 · 634 cites

Glutamate as a neurotransmitter in the healthy brain.

Journal of neural transmission (Vienna, Austria : 1996) · 2014 · 625 cites
Recent papers
Major research themes8
Glutamic Acid14Synapses6Astrocytes4Brain4Neuronal Plasticity4Neurons4gamma-Aminobutyric Acid3Hippocampus3
Journals, researchers & institutions
Top journals
  • The Journal of neuroscience : the official journal of the Society for Neuroscience8
  • International journal of molecular sciences7
  • Nature6
  • Nature communications4
  • Journal of neurochemistry3
  • Biomolecules2
Leading researchers
  • Andersen JV2
  • Danbolt NC2
  • Feilding A2
  • Hutten NRPW2
  • Kuypers KPC2
  • Mason NL2
  • Ramaekers JG2
  • Schousboe A2
Leading institutions
free-text, unnormalised
  • School of Medicine3
  • University of Copenhagen3
  • Institute of Basic Medical Sciences2
  • Lawrence Berkeley National Laboratory2
  • Maastricht University2
  • The Beckley Foundation2

Related diseases

5 conditions

Regulator-approved indications and conditions co-mentioned with this drug across the research literature. Number shows shared papers.

Related drugs

8 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Studied across 12 of the same disease areas as Glutamic Acid in the shared literature.

12 shared diseases2 shared papers

Studied across 6 of the same disease areas as Glutamic Acid in the shared literature.

6 shared diseases4 shared papers

Studied across 9 of the same disease areas as Glutamic Acid in the shared literature.

9 shared diseases1 shared paper

Studied across 7 of the same disease areas as Glutamic Acid in the shared literature.

7 shared diseases2 shared papers

Studied across 7 of the same disease areas as Glutamic Acid in the shared literature.

7 shared diseases1 shared paper

Studied across 5 of the same disease areas as Glutamic Acid in the shared literature.

5 shared diseases2 shared papers

Studied across 5 of the same disease areas as Glutamic Acid in the shared literature.

5 shared diseases1 shared paper

Studied across 3 of the same disease areas as Glutamic Acid in the shared literature.

3 shared diseases2 shared papers
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials